Design of DNA-based innovative computing system of digital comparison

doi:10.1016/j.actbio.2018.09.018

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	Design of DNA-based innovative computing system of digital comparison
	Zhou, Chunyang 1; Geng, Hongmei 1; Guo, Chunlei 1,2
	2018-10-15
发表期刊	ACTA BIOMATERIALIA
ISSN	1742-7061
卷号	80 页码:58-65
通讯作者	Guo, Chunlei(cyzhou@ciomp.ac.cn)
摘要	Despite great potential and extensive interest in developing biomolecule-based computing, the development of even basic molecular logic gates is still in its infancy. Digital comparator (DC) is the basic unit in traditional electronic computers, but it is difficult to construct a system for achieving large-scale integration. Here, we construct, for the first time, a novel logic computing system of DCs that can compare whether two or more numbers are equal. Our approach is by taking advantage of facile preparation and unique properties of graphene oxide and DNA. The DC system reported in this work is developed by the DNA hybridization and effective combination of GO and single-stranded DNA, which is regarded as the reacting platform. On the basis of this platform and reaction principle, we have developed 2-inputs, 3-inputs, and 4-inputs DCs to realize the comparison of two or more binary numbers. We predict that such a state-of-the-art logic system enables its functionality with large-scale input signals, providing a new direction toward. prototypical DNA-based logic operations and promoting the development of advanced logic computing. (C) 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
关键词	Digital comparator system Graphene oxide DNA Logic gate Computing
DOI	10.1016/j.actbio.2018.09.018
关键词[WOS]	LOGIC-CIRCUITS ; MAMMALIAN-CELLS ; GRAPHENE OXIDE ; ENZYME-FREE ; CONSTRUCTION ; PLATFORM ; GATES ; NANOSTRUCTURE ; OPERATIONS
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2017YFB1104700] ; Natural Science Foundation of China (NSFC)[21404015] ; Natural Science Foundation of China (NSFC)[61774155] ; Natural Science Foundation of China (NSFC)[61705227] ; Jilin Science and Technology Department Project[20150204019GX]
项目资助者	National Key Research and Development Program of China ; Natural Science Foundation of China (NSFC) ; Jilin Science and Technology Department Project
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000449133400004
出版者	ELSEVIER SCI LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/60529
专题	中国科学院长春光学精密机械与物理研究所
通讯作者	Guo, Chunlei
作者单位	1.Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, Guo China US Photon Lab, Changchun 130033, Jilin, Peoples R China 2.Univ Rochester, Inst Opt, Rochester, NY 14627 USA
推荐引用方式 GB/T 7714	Zhou, Chunyang,Geng, Hongmei,Guo, Chunlei. Design of DNA-based innovative computing system of digital comparison[J]. ACTA BIOMATERIALIA,2018,80:58-65.
APA	Zhou, Chunyang,Geng, Hongmei,&Guo, Chunlei.(2018).Design of DNA-based innovative computing system of digital comparison.ACTA BIOMATERIALIA,80,58-65.
MLA	Zhou, Chunyang,et al."Design of DNA-based innovative computing system of digital comparison".ACTA BIOMATERIALIA 80(2018):58-65.

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