CIOMP OpenIR
Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy
Hu, Yanfang1; He, Liang2; Ma, Weiqian1; Chen, Li1
2018-12-01
Source PublicationPOLYMER INTERNATIONAL
ISSN0959-8103
Volume67Issue:12Pages:1648-1654
Corresponding AuthorChen, Li(chenl686@nenu.edu.cn)
AbstractIn cancer treatment, it still is a curial challenge to enhance therapeutic efficacy and reduce side effects. A novel reduced graphene oxide-based nanoplatform (rGO/PDex) has been constructed to deliver an anticancer drug, bortezomib (BTZ), for photo-chemotherapy. The structure and properties of the nanoplatform were characterized. The obtained data strongly indicated that rGO/PDex had enhanced stability. Further, folic acid was introduced and the resulting rGO/PDexF nanoplatform exhibited improved cellular uptake due to the active targeting effect. The anticancer drug BTZ could be effectively encapsulated into the rGO-based nanoplatform and be released in a controlled manner. In vitro experiments demonstrated that BTZ-loaded rGO-based nanoparticles displayed enhanced therapeutic efficacy compared with the single chemotherapy, indicating the great potential of rGO-based nanoparticles for cancer treatments. (c) 2018 Society of Chemical Industry
Keywordreduced graphene oxide (rGO) non-covalent methods bortezomib (BTZ) delivery photothermal chemotherapy
DOI10.1002/pi.5689
WOS KeywordPROTEASOME INHIBITORS ; DRUG-DELIVERY ; PHOTO-CHEMOTHERAPY ; MULTIPLE-MYELOMA ; CANCER-CELLS ; MICELLES ; NANOPARTICLES ; NANOSHEETS ; UBIQUITIN ; GRAPHITE
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[21474012] ; National Natural Science Foundation of China[51273037] ; Jilin Science and Technology Bureau[20130206074GX] ; Jilin Science and Technology Bureau[20120729] ; New Century Excellent Talents in University of Jilin Province[2013-6] ; National Natural Science Foundation of China[21474012] ; National Natural Science Foundation of China[51273037] ; Jilin Science and Technology Bureau[20130206074GX] ; Jilin Science and Technology Bureau[20120729] ; New Century Excellent Talents in University of Jilin Province[2013-6] ; National Natural Science Foundation of China[21474012] ; National Natural Science Foundation of China[51273037] ; Jilin Science and Technology Bureau[20130206074GX] ; Jilin Science and Technology Bureau[20120729] ; New Century Excellent Talents in University of Jilin Province[2013-6]
Funding OrganizationNational Natural Science Foundation of China ; Jilin Science and Technology Bureau ; New Century Excellent Talents in University of Jilin Province
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
WOS IDWOS:000449675300007
PublisherWILEY
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ciomp.ac.cn/handle/181722/60324
Collection中国科学院长春光学精密机械与物理研究所
Corresponding AuthorChen, Li
Affiliation1.Northeast Normal Univ, Dept Chem, 5268 Renmin St, Changchun, Jilin, Peoples R China
2.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun, Jilin, Peoples R China
Recommended Citation
GB/T 7714
Hu, Yanfang,He, Liang,Ma, Weiqian,et al. Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy[J]. POLYMER INTERNATIONAL,2018,67(12):1648-1654.
APA Hu, Yanfang,He, Liang,Ma, Weiqian,&Chen, Li.(2018).Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy.POLYMER INTERNATIONAL,67(12),1648-1654.
MLA Hu, Yanfang,et al."Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy".POLYMER INTERNATIONAL 67.12(2018):1648-1654.
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