Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy

doi:10.1002/pi.5689

CIOMP OpenIR

	Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy
	Hu, Yanfang 1; He, Liang 2; Ma, Weiqian 1; Chen, Li 1
	2018-12-01
发表期刊	POLYMER INTERNATIONAL
ISSN	0959-8103
卷号	67 期号:12 页码:1648-1654
通讯作者	Chen, Li(chenl686@nenu.edu.cn)
摘要	In cancer treatment, it still is a curial challenge to enhance therapeutic efficacy and reduce side effects. A novel reduced graphene oxide-based nanoplatform (rGO/PDex) has been constructed to deliver an anticancer drug, bortezomib (BTZ), for photo-chemotherapy. The structure and properties of the nanoplatform were characterized. The obtained data strongly indicated that rGO/PDex had enhanced stability. Further, folic acid was introduced and the resulting rGO/PDexF nanoplatform exhibited improved cellular uptake due to the active targeting effect. The anticancer drug BTZ could be effectively encapsulated into the rGO-based nanoplatform and be released in a controlled manner. In vitro experiments demonstrated that BTZ-loaded rGO-based nanoparticles displayed enhanced therapeutic efficacy compared with the single chemotherapy, indicating the great potential of rGO-based nanoparticles for cancer treatments. (c) 2018 Society of Chemical Industry
关键词	reduced graphene oxide (rGO) non-covalent methods bortezomib (BTZ) delivery photothermal chemotherapy
DOI	10.1002/pi.5689
关键词[WOS]	PROTEASOME INHIBITORS ; DRUG-DELIVERY ; PHOTO-CHEMOTHERAPY ; MULTIPLE-MYELOMA ; CANCER-CELLS ; MICELLES ; NANOPARTICLES ; NANOSHEETS ; UBIQUITIN ; GRAPHITE
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[21474012] ; National Natural Science Foundation of China[51273037] ; Jilin Science and Technology Bureau[20130206074GX] ; Jilin Science and Technology Bureau[20120729] ; New Century Excellent Talents in University of Jilin Province[2013-6] ; National Natural Science Foundation of China[21474012] ; National Natural Science Foundation of China[51273037] ; Jilin Science and Technology Bureau[20130206074GX] ; Jilin Science and Technology Bureau[20120729] ; New Century Excellent Talents in University of Jilin Province[2013-6] ; National Natural Science Foundation of China[21474012] ; National Natural Science Foundation of China[51273037] ; Jilin Science and Technology Bureau[20130206074GX] ; Jilin Science and Technology Bureau[20120729] ; New Century Excellent Talents in University of Jilin Province[2013-6]
项目资助者	National Natural Science Foundation of China ; Jilin Science and Technology Bureau ; New Century Excellent Talents in University of Jilin Province
WOS研究方向	Polymer Science
WOS类目	Polymer Science
WOS记录号	WOS:000449675300007
出版者	WILEY
引用统计
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/60323
专题	中国科学院长春光学精密机械与物理研究所
通讯作者	Chen, Li
作者单位	1.Northeast Normal Univ, Dept Chem, 5268 Renmin St, Changchun, Jilin, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Hu, Yanfang,He, Liang,Ma, Weiqian,et al. Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy[J]. POLYMER INTERNATIONAL,2018,67(12):1648-1654.
APA	Hu, Yanfang,He, Liang,Ma, Weiqian,&Chen, Li.(2018).Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy.POLYMER INTERNATIONAL,67(12),1648-1654.
MLA	Hu, Yanfang,et al."Reduced graphene oxide-based bortezomib delivery system for photothermal chemotherapy with enhanced therapeutic efficacy".POLYMER INTERNATIONAL 67.12(2018):1648-1654.