Photo-Cross-Linkable Polymer Dots with Stable Sensitizer Loading and Amplified Singlet Oxygen Generation for Photodynamic Therapy

	Photo-Cross-Linkable Polymer Dots with Stable Sensitizer Loading and Amplified Singlet Oxygen Generation for Photodynamic Therapy
	Tang, Y.; H. B. Chen; K. W. Chang; Z. H. Liu; Y. Wang; S. N. Qu; H. Xu and C. F. Wu
	2017
发表期刊	Acs Applied Materials & Interfaces
卷号	9 期号:4
摘要	Photodynamic therapy (PDT) is a promising treatment modality for clinical cancer therapy. However, the therapeutic effect of PDT is strongly dependent on the property of photosensitizer. Here, we developed photo-cross-linkable semiconductor polymer dots doped with photosensitizer Chlorin e6 (Ce6) to construct a nanoparticle platform for photodynamic therapy. Photoreactive oxetane groups were attached to the side chains of the semiconductor polymer. After photo-cross-linking reaction, the Ce6-doped Pdots formed an interpenetrated structure to prevent Ce6 leaching out from the Pdot matrix. Spectroscopic characterizations revealed an efficient energy transfer from the polymer to Ce6 molecules, resulting in amplified generation of singlet oxygen. We evaluated the cellular uptake, cytotoxicity, and photodynamic effect of the Pdots in gastric adenocarcinoma cells. In vitro photodynamic experiments indicated that the Ce6-doped Pdots (similar to 10 mu g/mL) effectively killed the cancer cells under low dose of light irradiation (similar to 60 J/cm(2)). Furthermore, in vivo photodynamic experiments were carried out in tumor-bearing nude mice, which indicated that the Pdot photosensitizer apparently suppressed the growth of solid tumors. Our results demonstrate that the photo-cross-linkable Pdots doped with photosensitizer are promising for photodynamic cancer treatment.
收录类别	sci ; ei
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/59213
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Tang, Y.,H. B. Chen,K. W. Chang,et al. Photo-Cross-Linkable Polymer Dots with Stable Sensitizer Loading and Amplified Singlet Oxygen Generation for Photodynamic Therapy[J]. Acs Applied Materials & Interfaces,2017,9(4).
APA	Tang, Y..,H. B. Chen.,K. W. Chang.,Z. H. Liu.,Y. Wang.,...&H. Xu and C. F. Wu.(2017).Photo-Cross-Linkable Polymer Dots with Stable Sensitizer Loading and Amplified Singlet Oxygen Generation for Photodynamic Therapy.Acs Applied Materials & Interfaces,9(4).
MLA	Tang, Y.,et al."Photo-Cross-Linkable Polymer Dots with Stable Sensitizer Loading and Amplified Singlet Oxygen Generation for Photodynamic Therapy".Acs Applied Materials & Interfaces 9.4(2017).

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