Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers

	Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers
	Chang, Y. L.; X. D. Li; L. Zhang; L. Xia; X. M. Liu; C. X. Li; Y. L. Zhang; L. P. Tu; B. Xue; H. Y. Zhao; H. Zhang and X. G. Kong
	2017
发表期刊	Scientific Reports
卷号	7
摘要	Recent advances in upconversion nanophotosensitizers (UCNPs-PS) excited by near-infrared (NIR) light have led to substantial progress in improving photodynamic therapy (PDT) of cancer. For a successful PDT, subcellular organelles are promising therapeutic targets for reaching a satisfactory efficacy. It is of vital importance for these nanophotosensitizers to reach specifically the organelles and to perform PDT with precise time control. To do so, we have in this work traced the dynamic subcellular distribution, especially in organelles such as lysosomes and mitochondria, of the poly(allylamine)-modified and dual-loaded nanophotosensitizers. The apoptosis of the cancer cells induced by PDT with the dependence of the distribution status of the nanophotosensitizers in organelles was obtained, which has provided an in-depth picture of intracellular trafficking of organelle-targeted nanophotosensitizers. Our results shall facilitate the improvement of nanotechnology assisted photodynamic therapy of cancers.
收录类别	sci ; ei
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/58844
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Chang, Y. L.,X. D. Li,L. Zhang,et al. Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers[J]. Scientific Reports,2017,7.
APA	Chang, Y. L..,X. D. Li.,L. Zhang.,L. Xia.,X. M. Liu.,...&H. Zhang and X. G. Kong.(2017).Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers.Scientific Reports,7.
MLA	Chang, Y. L.,et al."Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers".Scientific Reports 7(2017).

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