Rapid and facile ratiometric detection of an anthrax biomarker by regulating energy transfer process in bio-metal-organic framework

	Rapid and facile ratiometric detection of an anthrax biomarker by regulating energy transfer process in bio-metal-organic framework
	Zhang, Y. H.; B. Li; H. P. Ma; L. M. Zhang and Y. X. Zheng
	2016
发表期刊	Biosensors & Bioelectronics
卷号	85
摘要	A ratiometric fluorescent sensor based on luminescent bio-metal-organic framework was prepared by exchanging both Tb3+ and Eu3+ cations into anionic bio-MOF-1. Due to a highly efficient energy transfer from Tb3+ to Eu3+ (> 89%), emission color of Tb/Eu@bio-MOF-1 was orange-red even though Tb3+ was the dominant content in this Tb/Eu co-doping material. More interestingly, this energy transfer process could be modulated by dipicolinic acid (DPA), an unique biomarker for bacillus spores. With DPA addition, corresponding DPA-to-Tb3+ energy transfer was gradually enhanced while the energy transfer from Tb3+ to Eu3+ was significantly weakened. By regulating the energy transfer process in Tb/Eu@bio-MOF-1, visual colorimetric sensing of DPA in porous MOF was realized for the first time. Detection limit of Tb/Eu@bio-MOF-1 for DPA was 34 nM, which was much lower than an infectious dosage of Bacillus anthracis spores (60 mu M) for human being. Besides, Tb/Eu@bio-MOF-1 showed a remarkable selectivity over other aromatic ligands and amino acids. More importantly, this porous ratiometric sensor worked equally well in human serum. These particularly attractive features of TbiEu@bio-MOF-1 made the direct, rapid and naked-eye detection of DPA for practical application possible. (C) 2016 Elsevier B.V. All rights reserved.
文章类型	期刊
收录类别	SCI ; EI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/57449
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Zhang, Y. H.,B. Li,H. P. Ma,et al. Rapid and facile ratiometric detection of an anthrax biomarker by regulating energy transfer process in bio-metal-organic framework[J]. Biosensors & Bioelectronics,2016,85.
APA	Zhang, Y. H.,B. Li,H. P. Ma,&L. M. Zhang and Y. X. Zheng.(2016).Rapid and facile ratiometric detection of an anthrax biomarker by regulating energy transfer process in bio-metal-organic framework.Biosensors & Bioelectronics,85.
MLA	Zhang, Y. H.,et al."Rapid and facile ratiometric detection of an anthrax biomarker by regulating energy transfer process in bio-metal-organic framework".Biosensors & Bioelectronics 85(2016).

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