Three-dimensional ghost imaging using acoustic transducer

	Three-dimensional ghost imaging using acoustic transducer
	Zhang, C.; S. X. Guo; J. Guan; J. S. Cao and F. L. Gao
	2016
发表期刊	Optics Communications
卷号	368
摘要	Fluorescent carbon dots (CDs) with a size smaller than 10 nm, excellent biocompatibility, and low to no cytotoxicity are considered as a rising star in nanomedicine. In this report, for the first time we demonstrate that green-emitting CDs with a carboxyl-rich surface can be employed as a trackable drug delivery agent for localized cancer treatment in a mouse model. The CDs are conjugated with the cancer drug, Doxorubicin (DOX), via non-covalent bonding, utilizing the native carboxyl groups on CDs and the amine moiety on DOX molecules. The pH difference between cancer and normal cells was successfully exploited as the triggering mechanism for DOX release. Our in vivo study demonstrated that the fluorescent CDs can serve as a targeted drug delivery system for localized therapy, and the stimuli-responsive non-covalent bonding between the nanodot carrier and the drug molecule is sufficiently stable in complex biological systems. Taken together, our work provides a strategy to promote the potential clinical application of CDs in cancer theranostics.
文章类型	期刊
收录类别	SCI ; EI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/57399
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Zhang, C.,S. X. Guo,J. Guan,et al. Three-dimensional ghost imaging using acoustic transducer[J]. Optics Communications,2016,368.
APA	Zhang, C.,S. X. Guo,J. Guan,&J. S. Cao and F. L. Gao.(2016).Three-dimensional ghost imaging using acoustic transducer.Optics Communications,368.
MLA	Zhang, C.,et al."Three-dimensional ghost imaging using acoustic transducer".Optics Communications 368(2016).

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