CIOMP OpenIR  > 中科院长春光机所知识产出
Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells
Zheng, M.; S. B. Ruan; S. Liu; T. T. Sun; D. Qu; H. F. Zhao; Z. G. Xie; H. L. Gao; X. B. Jing and Z. C. Sun
2015
Source PublicationAcs Nano
Volume9Issue:11Pages:11455-11461
AbstractA new type of carbon dots (CD-Asp) with targeting function toward brain cancer glioma was synthesized via a straightforward pyrolysis route by using a-glucose and L-aspartic acid as starting materials. The as-prepared CD-Asp exhibits not only excellent biocompatibility and tunable full-color emission, but also significant capability of targeting C6 glioma cells without the aid of any extra targeting molecules. In vivo fluorescence images showed high-contrast biodistribution of CD-Asp 15 min after tail vein injection. A much stronger fluorescent signal was detected in the glioma site than that in normal brain, indicating their ability to freely penetrate the blood brain barrier and precisely targeting glioma tissue. However, its counterparts, the CDs synthesized from a-glucose (CD-G), L-asparic acid (CD-A), or D-glucose and L-glutannic acid (CD-Glu) have no or low selectivity for glioma. Therefore, CD-Asp could act as a fluorescence imaging and targeting agent for noninvasive glioma diagnosis. This work highlights the potential application of CDs for constructing an intelligent nanomedicine with integration of diagnostic, targeting, and therapeutic functions.
Indexed BySCI ; EI
Document Type期刊论文
Identifierhttp://ir.ciomp.ac.cn/handle/181722/55535
Collection中科院长春光机所知识产出
Recommended Citation
GB/T 7714
Zheng, M.,S. B. Ruan,S. Liu,et al. Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells[J]. Acs Nano,2015,9(11):11455-11461.
APA Zheng, M..,S. B. Ruan.,S. Liu.,T. T. Sun.,D. Qu.,...&X. B. Jing and Z. C. Sun.(2015).Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells.Acs Nano,9(11),11455-11461.
MLA Zheng, M.,et al."Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells".Acs Nano 9.11(2015):11455-11461.
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