CIOMP OpenIR  > 中科院长春光机所知识产出
Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells
Zheng, M.; S. B. Ruan; S. Liu; T. T. Sun; D. Qu; H. F. Zhao; Z. G. Xie; H. L. Gao; X. B. Jing and Z. C. Sun
2015
发表期刊Acs Nano
卷号9期号:11页码:11455-11461
摘要A new type of carbon dots (CD-Asp) with targeting function toward brain cancer glioma was synthesized via a straightforward pyrolysis route by using a-glucose and L-aspartic acid as starting materials. The as-prepared CD-Asp exhibits not only excellent biocompatibility and tunable full-color emission, but also significant capability of targeting C6 glioma cells without the aid of any extra targeting molecules. In vivo fluorescence images showed high-contrast biodistribution of CD-Asp 15 min after tail vein injection. A much stronger fluorescent signal was detected in the glioma site than that in normal brain, indicating their ability to freely penetrate the blood brain barrier and precisely targeting glioma tissue. However, its counterparts, the CDs synthesized from a-glucose (CD-G), L-asparic acid (CD-A), or D-glucose and L-glutannic acid (CD-Glu) have no or low selectivity for glioma. Therefore, CD-Asp could act as a fluorescence imaging and targeting agent for noninvasive glioma diagnosis. This work highlights the potential application of CDs for constructing an intelligent nanomedicine with integration of diagnostic, targeting, and therapeutic functions.
收录类别SCI ; EI
文献类型期刊论文
条目标识符http://ir.ciomp.ac.cn/handle/181722/55535
专题中科院长春光机所知识产出
推荐引用方式
GB/T 7714
Zheng, M.,S. B. Ruan,S. Liu,et al. Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells[J]. Acs Nano,2015,9(11):11455-11461.
APA Zheng, M..,S. B. Ruan.,S. Liu.,T. T. Sun.,D. Qu.,...&X. B. Jing and Z. C. Sun.(2015).Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells.Acs Nano,9(11),11455-11461.
MLA Zheng, M.,et al."Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells".Acs Nano 9.11(2015):11455-11461.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Zheng-2015-Self-Targ(562KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zheng, M.]的文章
[S. B. Ruan]的文章
[S. Liu]的文章
百度学术
百度学术中相似的文章
[Zheng, M.]的文章
[S. B. Ruan]的文章
[S. Liu]的文章
必应学术
必应学术中相似的文章
[Zheng, M.]的文章
[S. B. Ruan]的文章
[S. Liu]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Zheng-2015-Self-Targeting Fluor.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。