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808 nm driven Nd3+-sensitized upconversion nanostructures for photodynamic therapy and simultaneous fluorescence imaging
Wang, D.; B. Xue; X. G. Kong; L. P. Tu; X. M. Liu; Y. L. Zhang; Y. L. Chang; Y. S. Luo; H. Y. Zhao and H. Zhang
2015
Source PublicationNanoscale
Volume7Issue:1Pages:190-197
AbstractThe in vivo biological applications of upconversion nanoparticles (UCNPs) prefer excitation at 700-850 nm, instead of 980 nm, due to the absorption of water. Recent approaches in constructing robust Nd3+ doped UCNPs with 808 nm excitation properties rely on a thick Nd3+ sensitized shell. However, for the very important and popular Frster resonance energy transfer (FRET)-based applications, such as photodynamic therapy (PDT) or switchable biosensors, this type of structure has restrictions resulting in a poor energy transfer. In this work, we have designed a NaYF4:Yb/Ho@NaYF4:Nd@NaYF4 core-shell-shell nanostructure. We have proven that this optimal structure balances the robustness of the upconversion emission and the FRET efficiency for FRET-based bioapplications. A proof of the concept was demonstrated for photodynamic therapy and simultaneous fluorescence imaging of HeLa cells triggered by 808 nm light, where low heating and a high PDT efficacy were achieved.
Indexed BySCI ; EI
Document Type期刊论文
Identifierhttp://ir.ciomp.ac.cn/handle/181722/55446
Collection中科院长春光机所知识产出
Recommended Citation
GB/T 7714
Wang, D.,B. Xue,X. G. Kong,et al. 808 nm driven Nd3+-sensitized upconversion nanostructures for photodynamic therapy and simultaneous fluorescence imaging[J]. Nanoscale,2015,7(1):190-197.
APA Wang, D..,B. Xue.,X. G. Kong.,L. P. Tu.,X. M. Liu.,...&H. Y. Zhao and H. Zhang.(2015).808 nm driven Nd3+-sensitized upconversion nanostructures for photodynamic therapy and simultaneous fluorescence imaging.Nanoscale,7(1),190-197.
MLA Wang, D.,et al."808 nm driven Nd3+-sensitized upconversion nanostructures for photodynamic therapy and simultaneous fluorescence imaging".Nanoscale 7.1(2015):190-197.
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