A highly effective in vivo photothermal nanoplatform with dual imaging-guided therapy of cancer based on the charge reversal complex of dye and iron oxide

	A highly effective in vivo photothermal nanoplatform with dual imaging-guided therapy of cancer based on the charge reversal complex of dye and iron oxide
	Chang, Y. L.; X. D. Li; X. G. Kong; Y. Li; X. M. Liu; Y. L. Zhang; L. P. Tu; B. Xue; F. Wu; D. B. Cao; H. Y. Zhao and H. Zhang
	2015
发表期刊	Journal of Materials Chemistry B
卷号	3 期号:42 页码:8321-8327
摘要	To enhance the treatment efficiency of photothermal therapy (PTT) with very little light-associated side effect, we have constructed a highly effective PTT nanoplatform for fluorescence and MRI dual imaging-guided PTT of cancer, based on IR806 dye and iron oxide complex functionalized with mPEG-PCL-G2.0PAMAM-Cit, which can be for charge-conversion for targeted accumulation in tumor. Combination of iron oxide nanoparticles and IR806 improve light to thermal conversion efficiency and lower light irradiation dose. In vitro and in vivo tests demonstrated that an effective dual imaging-guided PTT as low as 0.25 W cm(-2) could be realized under a light irradiation of 808 nm. These efforts highlight the potential of this PTT nanoplatform in "precision medicine''.
收录类别	SCI ; EI
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/55187
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Chang, Y. L.,X. D. Li,X. G. Kong,et al. A highly effective in vivo photothermal nanoplatform with dual imaging-guided therapy of cancer based on the charge reversal complex of dye and iron oxide[J]. Journal of Materials Chemistry B,2015,3(42):8321-8327.
APA	Chang, Y. L..,X. D. Li.,X. G. Kong.,Y. Li.,X. M. Liu.,...&H. Y. Zhao and H. Zhang.(2015).A highly effective in vivo photothermal nanoplatform with dual imaging-guided therapy of cancer based on the charge reversal complex of dye and iron oxide.Journal of Materials Chemistry B,3(42),8321-8327.
MLA	Chang, Y. L.,et al."A highly effective in vivo photothermal nanoplatform with dual imaging-guided therapy of cancer based on the charge reversal complex of dye and iron oxide".Journal of Materials Chemistry B 3.42(2015):8321-8327.

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