一种基于fMRI的味觉刺激装置的设计与验证

	一种基于fMRI的味觉刺激装置的设计与验证
其他题名	Design and Evaluation of a Gustometer for fMRI-study
	梁思
学位类型	硕士
导师	杨晓冬
	2015-10
学位授予单位	中国科学院大学
学位专业	机械工程
关键词	功能磁共振成像(Fmri) 味觉刺激微控制器 Labview
摘要	功能磁共振成像(fMRI)技术是一种新型的用于研究人脑功能活动的方法，通常作为一种揭示脑和思维关系的一种重要手段，在分析高级神经生理和神经心理活动方面具有重要的作用。目前，在已知感官中，视觉、听觉刺激装置发展比较成熟，国内外已有多家公司供应商用化产品，味觉刺激尚在理论阶段，通过味觉刺激进行相关脑科学研究相对较少。可能存在的原因主要有： 1) 味觉刺激装置通常需要根据各实验室实际要求进行搭建，没有一定的标准及成型的技术方案； 2) 缺乏专用的、自动化的且能够同时满足各种fMRI实验要求的味觉刺激装置； 3) 另外，味觉刺激装置中液体量的设定及对废液的处理方式因实验而异，液体量过大或长时间投送，需要单独设计废液处理装置; 4) 味觉fMRI实验的设计模式需要根据具体实验进行进一步研究。根据目前味觉刺激装置发展面临的问题，本文主要进行了一种fMRI的味觉刺激装置的设计与验证，并通过味觉fMRI实验对该设计的可用性进行了验证。具体成果如下： 1) 对目前已有的味觉刺激装置进行了分析和总结，从多路刺激、单一刺激、自动控制、成像同步、电磁兼容等方面进行需求分析，得出了味觉刺激装置的设计方案; 2) 方案中，使用LabVIEW软件编写上位机的软件平台，投送用户自定义的刺激序列；下位机利用以微控制器为核心的数字电路，完成液体的精确投送；另外，设计了味觉刺激装置的液体输送通路；同时通过数据采集卡将上位机的刺激序列发送至下位机执行，完成实时定量的味觉刺激输送; 3) 设计并使用搭建的味觉刺激装置对6个被试进行了fMRI味觉实验，得到了甜、咸味觉刺激下的脑激活图和部分ROI(Region of Interest)的时间曲线，验证了该味觉刺激装置的可用性。
其他摘要	Functional magnetic resonance imaging (fMRI) technology is a new method for studying the human brain functional activities and is usually used as an important method of revealing the relationship between brain and mind, at the same time it plays an important role in analysis of advanced neurophysiological and neuropsychological. There are many domestic and foreign companies who has supplied commercial product. Taste stimulation is still in the theoretical stage and has few related brain research. The main reasons are possible: 1) Taste stimulation device called gustatory is constructed by the actual requirements of the lab and experiments. There is no certain standards and technical programs molding; 2) The market lacks the dedicated and automated devices to meet the various requirements of fMRI experiments; 3) In the gustatory, how to set the amount of liquid and treat the waste liquid is different from experiments. If the liquid is overload or extended delivery, the separated waste treatment is necessary to be built; 4) The design patterns of taste fMRI experiments require future study based on the specific experiments. According to the problems in development of taste stimuli, this paper carried out the design and verification of an fMRI gustatory device, and through taste fMRI experiments verified the availability of stimulation design. Specific results are as follows: 1) From the already existing ,we analyzed and summarized that we can go on the demand analysis from multiple stimulation, a single stimulus, automatic control, image synchronization, electromagnetic compatibility and other aspects. In these requirements, the design of gustatory is presented; 2) For this purpose, we have designed and verified a computer-controlled gustatory device for delivering gustatory stimulation in fMRI environment. Host computer, whose interface is written in LabVIEW, can produce stimulation sequence based on user’s requirements; Slave computer, which is controlled by microcontroller unit, and can deliver precise amounts of liquid; at the same time, our gustatory also consists of the liquid delivery path. Through the data acquisition card, stimulation sequence is sent to the host computer, so that user can quantificationally deliver liquid in real-time; 3) We designed and evaluated the gustatory for taste stimulation with six subjects, and then got the activation map of sweet and salt taste and the ROI analysis results from parts of the activated brain regions. In these ways, the gustatory has been verified its usability.
语种	中文
文献类型	学位论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/49287
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	梁思. 一种基于fMRI的味觉刺激装置的设计与验证[D]. 中国科学院大学,2015.

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