An upconversion nanoparticle - Zinc phthalocyanine based nanophotosensitizer for photodynamic therapy

	An upconversion nanoparticle - Zinc phthalocyanine based nanophotosensitizer for photodynamic therapy
	Xia L.; Kong X. G.; Liu X. M.; Tu L. P.; Zhang Y. L.; Chang Y. L.; Liu K.; Shen D. Z.; Zhao H. Y.; Zhang H.
	2014
发表期刊	Biomaterials
ISSN	ISBN/0142-9612
卷号	35 期号:13 页码:4146-4156
摘要	Recent advances in NIR triggering upconversion-based photodynamic therapy have led to substantial improvements in upconversion-based nanophotosensitizers. How to obtain the high efficiency of singlet oxygen generation under low 980 nm radiation dosage still remains a challenge. A highly efficient nanophotosensitizer, denoted as UCNPs-ZnPc, was constructed for photodynamic therapy, which is based on near infrared (NIR) light upconversion nanoparticle (UCNP) and Zn(II)-phthalocyanine (ZnPc) photosensitizer (PS). The high 102 production efficiency came from the enhancement of the 660 nm upconversion emission of NaYF4:Yb3+, Er3+ UCNP with 25% Yb3+ doping, covalent assemblage of UCNP and ZnPc which significantly shortened the distance and enhanced the energy transfer between the two. The high O-1(2) production led to a secure and efficient PDT treatment, as evidenced by the in vivo test where UCNPs-ZnPc of 50 mg per kg body weight was locally injected into the liver tumor in mice, a low 980 nm radiation dose of 351 j/cm(2) (039 W/cm(2)) and short irradiation duration of 15 min were sufficient to perform image-guided PDT and caused the liver tumor inhibitory ratio of approximately 80.1%. Histological analysis revealed no pathological changes and inflammatory response in heart, lung, kidney, liver or spleen. (c) 2014 Elsevier Ltd. All rights reserved.
收录类别	SCI ; EI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/43729
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Xia L.,Kong X. G.,Liu X. M.,et al. An upconversion nanoparticle - Zinc phthalocyanine based nanophotosensitizer for photodynamic therapy[J]. Biomaterials,2014,35(13):4146-4156.
APA	Xia L..,Kong X. G..,Liu X. M..,Tu L. P..,Zhang Y. L..,...&Zhang H..(2014).An upconversion nanoparticle - Zinc phthalocyanine based nanophotosensitizer for photodynamic therapy.Biomaterials,35(13),4146-4156.
MLA	Xia L.,et al."An upconversion nanoparticle - Zinc phthalocyanine based nanophotosensitizer for photodynamic therapy".Biomaterials 35.13(2014):4146-4156.

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