A novel organic-inorganic hybrid monolithic column prepared in-situ in a microchip and its application for the determination of 2-amino-4-chlorophenol in chlorzoxazone tablets

	A novel organic-inorganic hybrid monolithic column prepared in-situ in a microchip and its application for the determination of 2-amino-4-chlorophenol in chlorzoxazone tablets
	Zhang J. L.; Chen G.; Tian M. M.; Li R. G.; Quan X. J.; Jia Q.
	2013
发表期刊	Talanta
ISSN	ISBN/0039-9140
期号	115
摘要	gamma-Alumina nanoparticles (gamma-Al2O3) were introduced to the conventional poly(methacrylic acid-co-ethylene glycol dimethacrylate) (MAA-co-EGDMA) monolith to prepare a novel organic-inorganic hybrid monolith, poly(MAA-co-EGDMA)-Al2O3 monolith. The polymerization was induced in-situ with UV irradiation in an ultraviolet transparent polymethyl methacrylate (PMMA) microfluidic chip. The monolith-based solid phase microextraction system was used for the on-line determination of 2-amino-4-chlorophenol (ACP) in chlorzoxazone tablets coupled with an optical fiber spectrophotometer. Several parameters affecting the adsorption/desorption, including sample pH value, sample flow rate, sampling time, eluent flow rate, and eluting time, were investigated in detail. Under the optimized conditions, limit of detection (LOD) and limit of quantification (LOQ) of the method were calculated to be 2.8 and 9.1 mu g L-1, respectively, with the relative standard deviation (RSD) of 3.1%. (C) 2013 Elsevier B.V. All rights reserved.
收录类别	SCI
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/40786
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Zhang J. L.,Chen G.,Tian M. M.,et al. A novel organic-inorganic hybrid monolithic column prepared in-situ in a microchip and its application for the determination of 2-amino-4-chlorophenol in chlorzoxazone tablets[J]. Talanta,2013(115).
APA	Zhang J. L.,Chen G.,Tian M. M.,Li R. G.,Quan X. J.,&Jia Q..(2013).A novel organic-inorganic hybrid monolithic column prepared in-situ in a microchip and its application for the determination of 2-amino-4-chlorophenol in chlorzoxazone tablets.Talanta(115).
MLA	Zhang J. L.,et al."A novel organic-inorganic hybrid monolithic column prepared in-situ in a microchip and its application for the determination of 2-amino-4-chlorophenol in chlorzoxazone tablets".Talanta .115(2013).

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