Fluorescent and paramagnetic core-shell hybrid nanoparticles for bi-modal magnetic resonance/luminescence imaging

	Fluorescent and paramagnetic core-shell hybrid nanoparticles for bi-modal magnetic resonance/luminescence imaging
	Di W.; Velu S. K. P.; Lascialfari A.; Liu C. X.; Pinna N.; Arosio P.; Sakka Y.; Qin W. P.
	2012
发表期刊	Journal of Materials Chemistry
ISSN	0959-9428
卷号	22 期号:38 页码:20641-20648
摘要	Well calibrated core-shell multifunctional nanoparticles for biomedical applications were synthesized by a multistep soft chemistry route. The core is composed of Gd(OH)CO3 center dot H2O spheres prepared via a urea-based homogeneous precipitation technique, while the shell is a homogeneous thin silica layer embedded with the fluorescent dye rhodamine B (RhB) prepared via a modified Stober process. The hybrid core-shell nanoparticles show a paramagnetic behavior with a specific saturation magnetization of 2.8 emu g(-1). The nuclear magnetic resonance relaxation measurements reveal that these systems could be used as T-1 and T-2 magnetic resonance imaging (MRI) contrast agents. Also, the resulting core-shell nanoparticles are fluorescent due to the presence of RhB entrapped inside the silica shell. When incubated with the human cervical carcinoma (HeLa) cells the core-shell composite particles exhibit bright intracellular fluorescence, indicating their capability for optical imaging in biology. Furthermore, the incorporation of organic dyes inside the silica matrix yields outstanding advantages such as significantly improved photostability of the dye and reduced cytotoxicity due to the protection of biocompatible silica shell. These features demonstrate that the magnetofluorescent core-shell nanoparticles prepared in our work have the potential to serve as a versatile imaging tool for smart detection or diagnosis in future biomedical engineering.
收录类别	SCI ; EI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/34539
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Di W.,Velu S. K. P.,Lascialfari A.,et al. Fluorescent and paramagnetic core-shell hybrid nanoparticles for bi-modal magnetic resonance/luminescence imaging[J]. Journal of Materials Chemistry,2012,22(38):20641-20648.
APA	Di W..,Velu S. K. P..,Lascialfari A..,Liu C. X..,Pinna N..,...&Qin W. P..(2012).Fluorescent and paramagnetic core-shell hybrid nanoparticles for bi-modal magnetic resonance/luminescence imaging.Journal of Materials Chemistry,22(38),20641-20648.
MLA	Di W.,et al."Fluorescent and paramagnetic core-shell hybrid nanoparticles for bi-modal magnetic resonance/luminescence imaging".Journal of Materials Chemistry 22.38(2012):20641-20648.