Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent

	Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent
	Liu Z.; Li Z. H.; Liu J. H.; Gu S.; Yuan Q. H.; Ren J. S.; Qu X. G.
	2012
发表期刊	Biomaterials
ISSN	0142-9612
卷号	33 期号:28 页码:6748-6757
摘要	Nanoparticulate imaging agents offer excellent diagnostic and therapeutic capabilities due to their intense and stable output, strong target binding via multiple ligands, as well as tunable biodistribution profiles. In the present work, we designed and synthesized PEGylated Yb2O3:Er nanoparticles with high Yb content in single particle (denoted as PEG-UCNPs) suitable for both X-ray CT imaging and up-conversion imaging. These PEG-UCNPs were facile to construct, possessed excellent stability against in vivo environment, and held long blood circulation time. Cell-cytotoxicity assay, hemolyticity, and post-injection histology analysis further demonstrated the excellent biocompatibility, indicating the feasibilities of PEG-UCNPs for in vivo applications. Compared with routinely used Iobitridol in clinic, well-prepared PEG-UCNPs provided much significantly enhanced contrast at a clinical 120 kVp voltage. By doping 5% Er3+ into the nanoparticles, PEG-UCNPs presented a long-term stable and nearly single-band red up-conversion emission upon continuous irradiation with an assistant of a 980 laser. In addition, pharmacokinetics, biodistribution, as well as clearance of nanoparticles were studied after intravenous injection in a mouse model, reflecting their overall safety. PEG-UCNPs composed of intrinsic up-conversion luminescence property, higher X-ray absorption over lobitridol, as well as excellent biocompatibility represented a nanoplatform for biomedicine applications. (C) 2012 Elsevier Ltd. All rights reserved.
收录类别	SCI ; EI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/34370
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Liu Z.,Li Z. H.,Liu J. H.,et al. Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent[J]. Biomaterials,2012,33(28):6748-6757.
APA	Liu Z..,Li Z. H..,Liu J. H..,Gu S..,Yuan Q. H..,...&Qu X. G..(2012).Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent.Biomaterials,33(28),6748-6757.
MLA	Liu Z.,et al."Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent".Biomaterials 33.28(2012):6748-6757.