Multi-targeting single fiber-optic biosensor based on evanescent wave and quantum dots

	Multi-targeting single fiber-optic biosensor based on evanescent wave and quantum dots
其他题名	论文其他题名
	Zhang Y. L.; Zeng Q. H.; Sun Y. J.; Liu X. M.; Tu L. P.; Kong X. G.; Buma W. J.; Zhang H.
	2010
发表期刊	Biosensors & Bioelectronics
ISSN	0956-5663
卷号	26 期号:1 页码:149-154
摘要	Highly sensitive, multi-analyte assay is a long-standing challenge fora single fiber-optic evanescent wave biosensor (FOB) In this paper, we report the first realization of such kind of FOB using CdSe/ZnS core/shell quantum dots (QDs) as labels. A direct binding assay model between antibody and antigen was employed to demonstrate the advantages of using QDs, instead of conventional fluorescein isothiocyanate (FITC). in lifting the sensitivity. Especially, multiplexed immunoassay was demonstrated in a single fiber FOB constructed with four differently sized QDs. Furthermore, the phenomenon that the affinity of the QD-labeled human IgG (QD-IgG) with goat anti-human IgG (anti-IgG) was lower than that of the FITC-labeled human IgG (FITC-IgG) was investigated and was ascribed to the differences in size and mass of the two. Our study indicates that the affinity could be improved by controlling the amount of IgG binding on QDs (C) 2010 Elsevier B V All rights reserved.
收录类别	SCI ; EI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/26162
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Zhang Y. L.,Zeng Q. H.,Sun Y. J.,et al. Multi-targeting single fiber-optic biosensor based on evanescent wave and quantum dots[J]. Biosensors & Bioelectronics,2010,26(1):149-154.
APA	Zhang Y. L..,Zeng Q. H..,Sun Y. J..,Liu X. M..,Tu L. P..,...&Zhang H..(2010).Multi-targeting single fiber-optic biosensor based on evanescent wave and quantum dots.Biosensors & Bioelectronics,26(1),149-154.
MLA	Zhang Y. L.,et al."Multi-targeting single fiber-optic biosensor based on evanescent wave and quantum dots".Biosensors & Bioelectronics 26.1(2010):149-154.

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