Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells

	Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells
其他题名	论文其他题名
	Liu K.; Liu X. M.; Zeng Q. H.; Zhang Y. L.; Tu L. P.; Liu T.; Kong X. G.; Wang Y. H.; Cao F.; Lambrechts S. A. G.; Aalders M. C. G.; Zhang H.
	2012
发表期刊	Acs Nano
ISSN	1936-0851
卷号	6 期号:5 页码:4054-4062
摘要	A highly efficient multifunctional nanoplatform for simultaneous upconversion luminescence (UCL) Imaging and photodynamic therapy has been developed on the basis of selective energy transfer from multicolor luminescent NaYF4:Yb3+,Er3+ upconversion nanoparticles (UCNPs) to photosensitizers (PS). Different from popular approaches based on electrostatic or hydrophobic Interactions, over 100 photosensitizing molecules were covalently bonded to every 20 nm UCNP, which significantly strengthened the UCNP-PS linkage and reduced the probability of leakage/desorption of the PS. Over 80% UCL was transferred to PS, and the singlet oxygen production was readily detected by Its feature emission at 1270 nm. Tests performed on JAR choriocarcinoma and NIH 3T3 fibroblast cells verified the efficient endocytosis and photodynamic effect of the nanoplatform with 980 nm Irradiation specific to JAR cancer cells. Our work highlights the promise of using UCNPs for potential Image-guided cancer photodynamic therapy.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.ciomp.ac.cn/handle/181722/24692
专题	中科院长春光机所知识产出
推荐引用方式 GB/T 7714	Liu K.,Liu X. M.,Zeng Q. H.,et al. Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells[J]. Acs Nano,2012,6(5):4054-4062.
APA	Liu K..,Liu X. M..,Zeng Q. H..,Zhang Y. L..,Tu L. P..,...&Zhang H..(2012).Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells.Acs Nano,6(5),4054-4062.
MLA	Liu K.,et al."Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells".Acs Nano 6.5(2012):4054-4062.

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